preventive effect of omega-3 fatty acids on ethinyl estradiolinduced hepatosteatosis in female wistar rat
نویسندگان
چکیده
background: hepatic steatosis due to estrogen therapyincreases the activity of inflammatory markers, particularly theactivity of tnfα which in turn induces more lipogenesis.omega-3 fatty acids are among the negative regulators of hepaticlipogenesis. objectives: in this research, the preventive effectof omega-3 fatty acids on estrogen-induced steatosis in rats wasevaluated. methods:2 mg/kg. bw/sc of 17α-ethiny-lestrasdiolwere injected into 25 female wistar rats in 5 equal groups(excluding the control group) over 10 consecutive days.simultaneously, 3 of estradiol-treated groups were orally given250, 500, and 1000 mg/kg. bw omega-3 fatty acids, respectively.at the end of the experiment, plasma alt, ast, and tnfαlevel were determined. histopathological changes in the liverwere also identified by the evaluation of samples stained withh&e and oil red o. results: the histological findingsrevealed hepatic microvesicular steatosis and fat deposit inethinylestradiol and, to a lesser extent, in the 250 mg/kg bwomega-3 fatty acids groups. the plasma levels of ast, alt, andtnfα significantly increased in the ethinylestradiol groupcompared to the control (p
منابع مشابه
Preventive effect of omega-3 fatty acids on ethinyl estradiolinduced hepatosteatosis in female wistar rat
BACKGROUND: Hepatic steatosis due to estrogen therapyincreases the activity of inflammatory markers, particularly theactivity of TNFα which in turn induces more lipogenesis.Omega-3 fatty acids are among the negative regulators of hepaticlipogenesis. OBJECTIVES: In this research, the preventive effectof omega-3 fatty acids on estrogen-induced steatosis in rats wasevaluated. METHODS:2 mg/kg. BW/S...
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عنوان ژورنال:
iranian journal of veterinary medicineناشر: دانشگاه تهران
ISSN 2251-8894
دوره 7
شماره 2 2013
کلمات کلیدی
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